Entering the month of December, Tampa Bay had just swept division rival Atlanta, avenging an ugly 56–14 defeat on TNF a year earlier.

On the defense side, the Buccaneers made improvements, ranking in the top ten in total yards and points allowed.

Drew Brees final throw was knocked down at the endline, and the Buccaneers snapped a 7-game losing streak dating back to the 2014 season.

Midway through the third quarter Vincent Jackson appeared to catch a 23-yard touchdown pass from Winston, but it was overturned after review, when it was determined that he did not get both feet down.

After his struggles the previous week, Buccaneers kicker Kyle Brindza missed two field goals and an extra point, and was cut by the club on Monday morning.

Tampa Bay snapped an 11-game home losing streak that dated back to December 2013, defeating Jacksonville by the score of 38–31.

Kirk Cousins threw a game-winning 6-yard touchdown pass to Jordan Reed with 24 seconds left in regulation.

However, Matt Ryan threw a game-tying touchdown pass to Julio Jones with 17 seconds left in regulation to force overtime.

Jameis Winston scrambled for a 10-yard touchdown run with 9:25 remaining, but the potential game-tying two point conversion attempt failed.

The Buccaneers attempted a hook and lateral play as time expired, but Trevin Wade of the Giants recovered the loose ball and ran it in for a touchdown the other way.

Trailing 6–3 with just over one minute left, Buccaneers quarterback Jameis Winston scrambled for a 4-yard run to the endzone, but lost the ball as he was up-ended just short of the goal line.

On the next play, Winston ran a naked bootleg for a 1-yard touchdown and a 10–6 Tampa Bay lead with 59 seconds remaining in regulation.

With 28 seconds left, Matt Cassel's pass intended for Dez Bryant was intercepted by Bradley McDougald in the endzone to secure the victory.

Doug Martin rushed for 235 yards, and Jameis Winston threw five touchdown passes (tying an NFL rookie record), as Tampa Bay routed the Eagles by a score of 45–17.

Matt Hasselbeck threw for 315 yards and two touchdowns passes to T. Y. Hilton as the Colts defeated Tampa Bay 25–12.

Tampa Bay made the score 24–17 after Jameis Winston threw a touchdown pass to Adam Humphries with just under 9 minutes left in regulation.

This would become the final home game for the Rams in St. Louis, as the team relocated back to Los Angeles for the 2016 season.