On the final ascent of Manayunk Wall, Lizzie Armitstead (Boels–Dolmans) won in a sprint, beating Elisa Longo Borghini (Wiggle–Honda) and Alena Amialiusik (Velocio–SRAM).

[8] After five rounds of the 2015 UCI Women's Road World Cup, there had been five different winners; Jolien D'Hoore at the Ronde van Drenthe,[9] Lizzie Armitstead at the Trofeo Alfredo Binda-Comune di Cittiglio,[10] Elisa Longo Borghini at the Tour of Flanders,[11] Anna van der Breggen at the La Flèche Wallonne Féminine,[12] and Giorgia Bronzini at the Tour of Chongming Island.

[13] Anna van der Breggen led the World Cup standings as the racing moved to Philadelphia, with 290 points, but her Rabo–Liv team had opted not to take part in the event.

[16] Team Hitec Products attacked each of the intermediate sprints, with Kirsten Wild providing a lead-out each lap for her teammate Emilie Moberg.

[16] Entering the final lap, the peloton remained close, although a number of riders had fallen behind or dropped out, particularly through the cobbled bends at the base of the Manayunk Wall.

Alena Amialiusik (Velocio–SRAM) and Shelley Olds (Bigla Pro Cycling Team) finished in third and fourth; the top four were all classified with the same time.