The 2015 Southern Miss Golden Eagles football team represented the University of Southern Mississippi in the 2015 NCAA Division I FBS football season as members of the West Division of Conference USA.

They were led by third-year head coach Todd Monken and played their home games at M. M. Roberts Stadium in Hattiesburg, Mississippi.

They finished the season 9–5, 7–1 in C-USA play to be champions of the West Division.

They represented the West Division in the Conference USA Football Championship Game where they lost to Western Kentucky.

The Golden Eagles will host CUSA foes North Texas, Old Dominion, UTEP, and UTSA, and will travel to Charlotte, Louisiana Tech, Marshall, and Rice.