The 2015 Tre Valli Varesine was the 95th edition of the Tre Valli Varesine single-day cycling race.

[1] The race started in Busto Arsizio and concluded in Varese, after 198 kilometres (123 mi).

The race consisted of the first 83 km from Busto Arsizio to Varese passing through several municipality of the Provincia di Varese, and then a final circuit in Varese that was repeated nine times [2] The race was won by Vincenzo Nibali (Astana), who attacked on the final climb and finished eight seconds ahead of the lead group.

Sergey Firsanov (RusVelo) was second, with Giacomo Nizzolo (Trek Factory Racing) third.

[1] The provisional start list include 19 teams:[2]