Canadian architect and indigenous activist Douglas Cardinal tried to file an injunction barring the Indians from using their name and logo for Games 3 and 4 in Toronto, but the application was dismissed by an Ontario judge.

In the bottom of the inning, Rajai Davis reached first on a force-out, stole second, moved to third on a wild pitch, and scored on Francisco Lindor's two-out single.

The Indians struck first off Marcus Stroman when Carlos Santana drew a leadoff walk in the first and scored on Mike Napoli's two out double, but their starter, Trevor Bauer had to leave the game in the bottom of the inning after allowing two walks and throwing 21 pitches due to a bloody pinkie finger as a result of being cut from a drone a few days earlier.

Napoli's home run in the fourth put the Indians back on top 2−1, but the Blue Jays tied it in the fifth off Zach McAllister when Ezequiel Carrera hit a leadoff triple and scored on Ryan Goins's groundout.

Cody Allen and Andrew Miller combined to pitch three shutout innings, striking out five batters as the Indians took a 3–0 series lead.

Kluber walked two straight to lead off the fourth before Ezequiel Carrera's one-out RBI single made it 2−0 Blue Jays.

The Indians cut it to 2−1 in the fifth off Aaron Sanchez when Coco Crisp walked with one out, moved to second on a wild pitch, and scored on Roberto Pérez's double.

Ryan Merritt, Bryan Shaw, Andrew Miller, and Cody Allen shutout the Blue Jays as the Indians' 3−0 win gave them their first trip to the World Series since 1997.

Allen earned his fifth save of the postseason as Troy Tulowitzki popped up to first baseman Santana in foul territory to end the game and series.

The Indians also set an MLB record with the lowest batting average by a winning team in a postseason series, hitting just .168 against the Blue Jays.

On December 23, 2016, the Cleveland Indians signed Edwin Encarnación, who had become a free agent after 6+1⁄2 years with the Toronto Blue Jays, and had declined the team's qualifying offer.