Contested over 367 laps on the 1.366-mile (2.198 km) egg-shaped oval, it was the 25th race of the 2016 NASCAR Sprint Cup Series season.

Brad Keselowski made his way to a second-place finish, The race had eight lead changes among different drivers and ten cautions for 52 laps.

The preliminary entry list for the race included 40 cars and was released on August 27, 2016 at 1:52 p.m. Eastern time.

NASCAR cancelled all Friday activities and rescheduled both practice sessions in place of qualifying for Saturday due to rain from Hurricane Hermine.

[29] Under mostly sunny South Carolina skies, Kevin Harvick led the field to the green flag at 6:26 p.m. Not much happened during this first run of the race outside of Clint Bowyer making an unscheduled stop for a flat tire on lap 23.

Austin Dillon and Michael McDowell were black-flagged for speeding and forced to serve a pass through penalty.

Trevor Bayne spun out at the entrance of pit road and brought out the first caution of the race on lap 96.

Jimmie Johnson, who was black-flagged before the caution flew for "illegal body modification," was forced to serve a pass through penalty.

The second caution of the race flew on lap 114 after Brian Scott got loose exiting turn 2 and spun out.

Keselowski drove away from the field for a time, but was chased down by Harvick who passed him in turn 2 to retake the lead on lap 141.

The fourth caution of the race flew on lap 213 after Johnson got loose exiting turn 4, spun down the track and hit the inside wall on the frontstretch.

The sixth caution of the race flew on lap 260 for Greg Biffle hitting the wall in turn 4.

The seventh caution of the race flew with 87 laps to go for a two-car wreck in turn 2 involving A. J. Allmendinger and Ryan Blaney.

Rounding turn 2, Paul Menard suffered a left-rear tire blowout, got loose, clipped Kurt Busch and sent him backwards into the wall.

Harvick reeled him in to take the lead just as the 10th caution of the race flew for a two-car wreck in turn 2 involving Aric Almirola and Bowyer.

It's awareness month for both of those diseases, so big day for us there, but just can't say enough about this team and Barney Visser (team owner) and Toyota and TRD (Toyota Racing Development) – the engines have been unbelievable this year – and Bass Pro Shops and Furniture Row, Denver Mattress and everybody that's made this possible.

It's awareness month for both of those diseases, so big day for us there, but just can't say enough about this team and Barney Visser (team owner) and Toyota and TRD (Toyota Racing Development) – the engines have been unbelievable this year – and Bass Pro Shops and Furniture Row, Denver Mattress and everybody that's made this possible.

It was worth the wait for sure, so we'll do some celebrating tonight and just can't thank everybody enough again – everybody at (Joe) Gibbs (Racing), all those guys, great teammates – just so many people I need to thank.

You get into position to win races and they continually step on their toes and don’t make it happen.’’[39] During his post-race media availability, he went further saying he's "over being a cheerleader.

Those guys get paid a lot of money to perform on pit road and cheerleading hasn't really been working.

You've got to get after it on pit road and do your job.”[40] On the Wednesday following the race, Larson and Newman – whose cars failed post-race inspection – were docked 15 points each, and their crew chiefs were both fined over $20,000.

Rick Allen, two–time Darlington winner Jeff Burton and Steve Letarte had the call in the booth for the race.

Dave Burns, Mike Massaro, Marty Snider and Kelli Stavast handled pit road on the television side.