Home games were played at Doak Campbell Stadium in Tallahassee, Florida.

Safety Jalen Ramsey and kicker Roberto Aguayo went on to be selected in the NFL draft.

Prior to the start of the 2016 season, Dalvin Cook, Derwin James, Roderick Johnson and DeMarcus Walker were named pre-season All-Americans.

[1] In the pre-season media poll, Florida State was picked to finish second in the ACC Atlantic and Dalvin Cook was picked as runner-up for ACC Player of the Year[2] while Cook, Roderick Johnson, Travis Rudolph, DeMarcus Walker, and Derwin James were named to the pre-season All-ACC team.

Defensive end DeMarcus Walker and running back Dalvin Cook were named consensus All-Americans.