He was selected by the Tampa Bay Buccaneers in the second round of the 2016 NFL draft, unusually high for a special teams player.

Despite an accomplished collegiate career at Florida State, Aguayo is considered to be among the biggest busts in recent NFL history.

[2][3][4] He then had stints with the Chicago Bears, the Carolina Panthers, the Los Angeles Chargers and the New England Patriots between 2017 and 2021 without seeing any regular season game action.

Aguayo led the Atlantic Coast Conference (ACC) in points with 157 and field goals converted with 21 in the 2013 season.

[1] Aguayo announced his intention to forgo his senior season on January 6, 2016, to enter the 2016 NFL draft.

[1] In July 2021, ESPN named Aguayo as part of their all-time collegiate "Special Teams Mount Rushmore", alongside Sebastian Janikowski, Shane Lechler, and Braden Mann.

[22] On December 26, Aguayo was signed to the Patriots' practice squad after spending nearly two full seasons as a free agent.

[25] Aguayo was competing with veteran Nick Folk once again and undrafted free agent Quinn Nordin.