The 2016 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts.

It was the fourth edition of the tournament which was part of the 2016 ATP Challenger Tour.

It took place in Mouilleron-le-Captif, France between 7 and 13 November 2016.

The following players received wildcards into the singles main draw: The following player entered the main draw using a special exemption: The following players received entry from the qualifying draw: