The 2016 Las Vegas Challenger was a professional tennis tournament played on hard courts.

It was the second edition of the revamped tournament which was the part of the 2016 ATP Challenger Tour.

It took place in Las Vegas, United States between 17 and 23 October 2016.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as a special exempt: The following players received entry from the qualifying draw: The following player entered as a lucky loser: