The 2016 Istanbul Open (also known as the TEB BNP Paribas Istanbul Open for sponsorship purposes) was a men's tennis tournament played on outdoor clay courts.

It was the second edition of the Istanbul Open, and an ATP World Tour 250 event.

It took place at the Koza World of Sports Arena in Istanbul, Turkey, from 25 April until 1 May 2016.

Unseeded Diego Schwartzman won the singles title.

Diego Schwartzman defeated Grigor Dimitrov, 6–7(5–7), 7–6(7–4), 6–0 Flavio Cipolla / Dudi Sela defeated Andrés Molteni / Diego Schwartzman, 6–3, 5–7, [10–7] The following players received wildcards into the main draw: The following players received entry via the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: