The 2016 Mid-Season Invitational was the second event of the Mid-Season Invitational (MSI), a League of Legends tournament by Riot Games.

It took place from March 4 to March 15, 2016, in Shanghai Oriental Sports Center, Pudong, Shanghai, China.

[1][2][3][4][5] The participants were 6 winning teams of the Spring Seasons in their respective regions: 5 teams from North America (NA LCS), Europe (EU LCS), China (LPL), South Korea (LCK), Taiwan/Hong Kong/Macau (LMS) and a team from Wildcard regions (Brazil, CIS, Japan, Latin America, Oceania, Southeast Asia) that won the Mid-Season International Wildcard Invitational (IWCI).

SK Telecom T1 from South Korea won their first MSI title after defeating Counter Logic Gaming from North America 3–0 in the final.

Shanghai was the city chosen to host the competition.