The 2016 Northwestern State Demons football team represented Northwestern State University as a member of the Southland Conference during the 2016 NCAA Division I FCS football season.

Led by fourth-year head coach Jay Thomas, the Demons compiled an overall record of 1–10 with a mark of 0–9 in conference play, placing last out of 11 teams in the Southland.

Northwestern State played home games at Harry Turpin Stadium in Natchitoches, Louisiana.

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