[3] Purdue hired former Syracuse Orange football offensive coordinator Tim Lester as quarterbacks coach.

[5] Just two days later, Purdue announced that they had completed their coaching staff with the hiring of Lincoln Southwest High School assistant Ross Els as the defensive coordinator.

The Boilermakers hosted Big Ten foes Iowa, Northwestern, Penn State, and Wisconsin, and traveled to Illinois, Indiana, Maryland, Minnesota, and Nebraska.

The radio announcers are Tim Newton with play-by-play, Pete Quinn with color commentary, and Kelly Kitchel with sideline reports.

[31] Purdue opened the scoring in the first quarter with a 3-yard touchdown rush and added to its lead with a 1-yard run by David Blough.

After Missouri transfer Maty Mauk struggled in his first drive, Eastern Kentucky opened their scoring near the end of the first quarter with a 10-yard pass to Dan Crimmins from Bennie Coley and added a two-point conversion with a Neiko Creamer rush.

[39] Purdue began the game with the loss of both of their starting offensive tackles, Martesse Patterson and Matt McCann for personal and injury reasons.

[42] Following its game against Nevada, Purdue began its Big Ten portion of the schedule when it traveled to the Maryland Terrapins.

After a first down run by Worship, Dellinger kicked a 28-yard field goal to give Purdue the victory.

[1] After its homecoming game against Iowa, Purdue traveled to Lincoln to face its in-division rival, the Nebraska Cornhuskers.

[57] After a failed running back pass by Markell Jones was intercepted, Tommy Armstrong Jr. ran 22-yards to give Nebraska its first lead just 26 seconds into the game.

On the ensuing drive, Purdue drove the length of the field and scored on a 1-yard touchdown reception by DeAngelo Yancey from David Blough.

After the defense forced a punt, Purdue's offense drove 55-yards completed by a 1-yard touchdown pass from David Blough to Cameron Posey.

Penn State would tied the game when Trace McSorley found Chris Godwin on a crossing pattern that went 38-yards for a touchdown.

Purdue opened the second half with the ball, but on their first 3rd down, Blough was intercepted by Brandon Smith.

Penn State extended their lead with a 4-yard touchdown run by Andre Robinson, and a 29-yard field goal by Davis.

After 3 series of stops by both teams, Blough found Cameron Posey on a slant route, take the pass 89-yards for a touchdown.

Purdue used the time left to find Brycen Hopkins for a 2-yard touchdown pass from Blough, giving the Boilermakers a 28–23 halftime lead.

After forcing a Golden Gophers punt, Purdue was driving, when on a 4th and 1 Jack Wegher fumbled giving Minnesota the ball back.

[69] Purdue opened the game driving 61-yards and kicking a 26-yard field goal by J. D. Dellinger to give them an early lead.

Wisconsin scored their first points of the game halfway through the second quarter when Alec Ingold punched the ball in from the 1-yard line.

After the kickoff, Purdue's first play was intercepted by T. J. Watt, who batted a David Blough pass to himself, and returned the ball 17 yards for a touchdown.

[74] Following its home finale against Wisconsin, Purdue faced its arch-rivals, the Indiana Hoosiers, in the 118th meeting of "Old Oaken Bucket".

[77] After Markus Bailey intercepted a Richard Lagow pass and returned it to the Indiana one yard line, Purdue opened up the scoring with a 1-yard touchdown run by Markell Jones.

After an Indiana punt, Blough was intercepted by Jonathan Crawford, who was able to return the ball in Purdue territory, setting up a 29-yard Griffin Oakes field goal.

After the two teams exchanged punts, Purdue scored with 1:50 left in the first half on a 10-yard Cameron Posey touchdown from Blough, however Dellinger's point after attempt was blocked, giving Indiana a 17–16 halftime lead.

After Purdue was forced to punt, Indiana drove 61 yards concluding with a 1-yard touchdown run by Devine Redding to re-gain the lead for the Hoosiers.

Blough was able to drive and lead the Boilermakers to the Hoosiers 27-yard line, where on 4th and 14, he was intercepted again by Crawford in the end zone with 1:13 remaining.

Indiana decided to attempt to run out the clock when Diamont ran backwards into his own end zone where he was tackled by Jake Replogle for a safety, making the score 26–24 with 1 second remaining.

On the free kick, Brian Lankford-Johnson's lateral pass was caught by Crawford and he took a knee,[78] sealing Indiana's fourth straight victory over Purdue.