At the 2008 Region I-5A Meet, he took gold in the 400-meter dash, with a PR of 48.92, and ran the lead leg on the West Monroe 4 × 200m and 4 × 400m squads, helping them capture the state title in both events.

Sources: Mingo attended Louisiana State University, and played for coach Les Miles's LSU Tigers football team from 2009 to 2012.

[18][19] Mingo was immediately moved to outside linebacker by defensive coordinator Ray Horton and competed against Jabaal Sheard for a starting role throughout training camp.

[20] On August 15, 2013, Mingo suffered a bruised lung during the Browns' 24–6 win against the Detroit Lions during their second preseason game.

[21] Head coach Rob Chudzinski named Mingo a backup outside linebacker, behind Jabaal Sheard and Paul Kruger, to begin the regular season.

[23] On September 29, 2013, Mingo earned his first career start in place of Jabaal Sheard who was inactive due to a knee injury.

[28] Head coach Mike Pettine named Mingo and Paul Kruger the starting outside linebackers to begin the regular season.

[32] Mingo entered training camp slated as the starting strongside linebacker after Jabaal Sheard departed during free agency.

[33] Head coach Mike Pettine retained Mingo and Paul Kruger as the starting outside linebackers to begin the regular season.

[38] On January 4, 2016, the Cleveland Browns fired head coach Mike Pettine and general manager Ray Farmer after they finished the season with a 3–13 record.

[42] Head coach Bill Belichick named Mingo the fourth outside linebacker on the Patriots' depth chart to start the regular season.

[47] On January 14, 2017, Mingo appeared in his first career playoff game as the Patriots defeated the Houston Texans 34–16 in the AFC Divisional Round.

[49] On February 5, 2017, Mingo appeared in Super Bowl LI and recorded two solo tackles as the Patriots defeated the Atlanta Falcons 34–28.

[53][54] Head coach Chuck Pagano named Mingo the backup strongside linebacker, behind John Simon, to begin the regular season.

[57] Mingo finished his lone season with the Indianapolis Colts with 47 combined tackles (35 solo), two pass deflections, and two sacks in 16 games and six starts.

[61] Head coach Pete Carroll named Mingo and K. J. Wright the starting outside linebackers to begin the regular season.

[63] He finished the season with a career-high 48 combined tackles (37 solo), two forced fumbles, a pass deflection, and one sack in 16 games and 14 starts.

[64] On August 31, 2019, the Seahawks traded Mingo along with outside linebacker Jacob Martin and a 2020 third-round pick to the Houston Texans in exchange for Jadeveon Clowney.

[68][69] In a week 9 loss to the Tennessee Titans, Mingo was credited with the first rushing attempt of his career, gaining 11 yards and a first down after taking a hand-off on a fake punt.

[74] On July 7, 2021, Mingo was arrested in Arlington, Texas, on a second-degree felony charge of indecency and sexual contact with a minor.