Contested over 267 laps on the 1.5-mile (2.4 km) speedway, it was the 18th race of the 2016 NASCAR Sprint Cup Series.

During Coca-Cola 600 race weekend, NASCAR announced they would test changes to the aero package at Michigan and Kentucky.

[15] The preliminary entry list for the race included forty cars and was released on July 1, 2016, at 3:17 pm ET.

[17] Jimmie Johnson went to his backup car after slamming the wall exiting turn 4 early in the session.

[20] Carl Edwards was the fastest in the final practice session with a time of 28.808 and a speed of 187.448 mph (301.668 km/h).

[21] Kurt Busch dropped to the rear of the field after switching to his backup car because of a wreck in the closing minutes of final practice.

[22] Under clear evening Kentucky skies, Kevin Harvick led the field to the green flag at 7:50.

Exiting turn 4, Jimmie Johnson made contact with Ryan Blaney and sent himself spinning into the wall.

The fourth caution of the race flew on lap 54 after Joey Logano suffered a right-front tire blowout and slammed the wall in turn 3.

The fifth caution of the race flew on lap 80 for Matt DiBenedetto after his car slammed the wall in turn 3.

[27] Blaney said that the "restart was pretty hectic from the beginning with the 78 getting loose and it kind of put everybody in a bad spot, and it wound up with us being in the middle of three-wide into three.

A. J. Allmendinger, Buescher, Ty Dillon, Larson, Danica Patrick, Regan Smith, Scott and Cole Whitt were all collected in the melee.

Harvick hit pit road on lap 147 and handed the lead to Austin Dillon.

She pitted the next lap and the lead cycled to Truex just as the eighth caution of the race flew for Regan Smith who suffered a right-front tire blowout and slammed the wall in turn 3.

The ninth caution of the race flew with 108 laps to go for a single-car spin in turn 3 involving Clint Bowyer.

The 10th caution of the race flew with 96 laps to go for a single-car wreck on the frontstretch involving A. J. Allmendinger.

The 11th caution of the race flew with 74 laps to go after Landon Cassill slammed the wall in turn 2.

Truex was forced to serve a pass-through penalty for passing Harvick on entry to pit road.

In the final 10 laps, a number of cars began pitting so to have enough fuel to make the finish.

The car wouldn't run, but we're back here in Victory Lane and what a great Saturday night.

We were getting such good fuel mileage with our TRD (Toyota Racing Development) engine, I think we might have had a little extra there.

Rick Allen, Jeff Burton and Steve Letarte had the call in the booth for the race.

Dave Burns, Mike Massaro, Marty Snider and Kelli Stavast reported from pit lane during the race.