The 2016 South Alabama Jaguars football team represented the University of South Alabama in the 2016 NCAA Division I FBS football season.

The Jaguars played their home games at Ladd–Peebles Stadium in Mobile, Alabama, and competed in the Sun Belt Conference.

They were led by head coach Joey Jones, who was in his eighth year with the team.

On October 13, 2016, LSU canceled its game against the Jaguars on November 19 due to scheduling issues after Hurricane Matthew.

[2][3] On October 15, 2016, the Jaguars announced they will host the Presbyterian Blue Hose on November 19; the Blue Hose's game with Florida on that day was also canceled under the same circumstances.