The 2016 Mississippi State Bulldogs football team represented Mississippi State University in the 2016 NCAA Division I FBS football season.

The Bulldogs played their home games at Davis Wade Stadium in Starkville, Mississippi and competed in the Western Division of the Southeastern Conference (SEC).

Despite having a 5–7 record, the first losing season since 2009, Mississippi State qualified for a bowl bid due to their high APR score.

Mississippi State beat the Miami RedHawks in the St. Petersburg Bowl to finish the season at 6–7.

The Bulldogs will host SEC foes Arkansas, Auburn, South Carolina, and Texas A&M, and will travel to Alabama, Kentucky, LSU, and Ole Miss.