The 2016 Tampa Bay Rays season was the Rays' 19th season of Major League Baseball and the ninth as the "Rays" (all at Tropicana Field).

After starting the season 31–32, the Rays went 37–62 across their final 100 games, including a dismal 3–24 stretch before the All-Star Break, to finish at 68–94, their worst record since the 2007 season.

In March 2016, the Rays traveled to Cuba to play an exhibition game against the Cuba national baseball team to accompany Barack Obama's visit to Cuba, the first United States presidential visit to Cuba in 88 years.

With Obama and Raúl Castro in attendance, the Rays beat Cuba 4–1.

Infielders Coaches Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; AVG = Batting average; SLG = Slugging average Source:[1] Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks allowed; SO = Strikeouts Source:[2]