The 2016 Tour de San Luis was a road cycling stage race that took place in Argentina between 18 and 24 January 2016.

He lost this the following day to Peter Koning (Drapac Professional Cycling), who won in a solo breakaway.

The first mountain stage was won by Eduardo Sepúlveda (Fortuneo–Vital Concept), giving him a three-second advantage over Dayer Quintana (Movistar Team).

The final mountain stage was won by Miguel Ángel López (Astana), with Quintana taking enough time out of Sepúlveda to put himself into the race lead.

The final sprint stage was won by Jakub Mareczko (Italy), with Quintana taking the overall win.

Many of the South American riders use the Tour de San Luis to prepare for their national championships.

Other South American riders with a chance of victory included Rodolfo Torres (Androni Giocattoli–Sidermec), who was second in 2015, and Eduardo Sepúlveda (Fortuneo–Vital Concept).

These included Peter Sagan (Tinkoff), who was looking for his first victory in the rainbow jersey he wore as the 2015 road race world champion, Fernando Gaviria (Etixx–Quick-Step), who won two races in the 2015 Tour de San Luis and Elia Viviani (riding for the Italian national team).

There is another mountain stage on the sixth day, however; it finishes on the Filo Sierras Comechingones, which is described by Cycling Weekly as "fearsome".

[4] Stage 1 was a 21-kilometre (13 mi) team time trial around El Durazno over rolling terrain, with no significant or difficult climbs.

[9] Drapac Professional Cycling were the first team to set a time: they finished in 24' 53" with an average speed of 50.6 kilometres per hour (31.4 mph).