Incumbent senator John Boozman won re-election to a second term in office, becoming the first Republican senator reelected in the history of the state.

Former U.S. Attorney Conner Eldridge was the only Democrat to declare his candidacy.

The Libertarian Party of Arkansas held a special nominating convention on October 24, 2015, to select nominees for elections in 2016.

Frank Gilbert was selected as the nominee for the U.S. Senate race.

[6] with Mike Beebe Boozman won all 4 congressional districts[28] Official campaign websites (Archived)