If Paul had become the Republican presidential (or vice-presidential) nominee, state law would have prohibited him from simultaneously running for re-election.

[2][3][4] Paul spent his own campaign money in the 2014 legislative elections, helping Republican candidates for the State House in the hopes of flipping the chamber, thus allowing the legislature to pass the bill (Democratic governor Steve Beshear's veto could have been overridden with a simple majority).

Other options that were open to him included running for both offices and leaving it to Democratic Secretary of State Alison Lundergan Grimes to remove him from the ballot; attempting to replace Grimes in the 2015 elections with a Republican secretary of state who would not enforce the law; filing a lawsuit against the law; and running for president in every state except for Kentucky, where he could have run for re-election and hoped to win the presidency without Kentucky's electoral college votes.

[13] David M. Drucker of The Washington Examiner reported in the same month that Kentucky Republican leaders were concerned that Paul's actions could mean that if he wins the Republican presidential nomination and is renominated for the Senate, he could either be disqualified from the Senate ballot and the state party blocked from replacing him, which would hand the seat to the Democrats, or he could be disqualified from the presidential ballot, which would see the Democratic presidential nominee pick up Kentucky's 8 electoral college votes.

[15] However, on February 3, 2016, Rand Paul dropped out of the 2016 presidential campaign, allowing him to focus on his reelection bid.