Incumbent Republican Senator Roy Blunt won re-election to a second term in office, defeating Democratic Missouri Secretary of State Jason Kander.

[1][2] Despite losing, Kander's margin of defeat was 15.7 percentage points closer than that of Democratic presidential nominee Hillary Clinton in the concurrent presidential election in the state.

Despite being considered an "establishment" Republican, Blunt did not face serious Tea Party opposition due to his efforts to cultivate relationships with activists in Missouri, his effectiveness at "threading the needle" by keeping conservative and establishment Republicans fairly satisfied, and the open gubernatorial election, which attracted the most attention from Republicans.

Representatives Individuals Organizations Vice presidents Governors U.S.

Representatives Statewide Officials Organizations Blunt won 6 of 8 congressional districts.