Wyoming voters chose electors to represent them in the Electoral College via a popular vote pitting the Republican Party's nominee, businessman Donald Trump, and running mate Indiana Governor Mike Pence against Democratic Party nominee, former Secretary of State Hillary Clinton and her running mate, Virginia Senator Tim Kaine.

On March 1 and April 9, 2016, in the presidential primaries, Wyoming voters expressed their preferences for the Democratic, Republican, Libertarian, and Constitution parties' respective nominees for president.

[2] Wyoming, a solidly Republican state, has not voted for a Democrat in a presidential election since it went for Lyndon B. Johnson in 1964.

Clinton's 21.88% vote share was the lowest of any major party presidential nominee in Wyoming history.

[5] In the 2012 presidential election, incumbent President Barack Obama received less than 28% of the votes, trailing Mitt Romney by more than 40 points.