The regular season begins on 3 September 2017 and ends on 8 April 2018.
The seven best runners-up are determined by the following parameters, in this order: The two best third-placed will qualify for the Copa del Rey.
The seven best third-placed are determined by the following parameters, in this order: The seven group champions and the best runner-up were qualified to this competition whose winner will play the 2018–19 UEFA Youth League.
The draw was held in Ciudad Real on 10 April 2018.
[1] The quarterfinals and semifinals will be played in Ciudad Real and Puertollano, while the final at Estadio Rey Juan Carlos I, in Ciudad Real.