The 2021–22 División de Honor Juvenil de Fútbol was the 36th season of the highest-level under-19 football league competition in Spain since its establishment.
The format of the competition returned to normal after some changes to the previous season caused by the COVID-19 pandemic in Spain.
Teams were divided into seven regionalised groups playing each other twice, with the champion of each group and the best runner-up qualifying for the 2022 Copa de Campeones, and four teams in each group relegated to the Liga Nacional.
Group 1[3] Group 2[4] Group 3[5] Group 4[6] Group 5[7] Group 6[8] Group 7[9] The quarter-finals were played over a single leg at the home ground of one of the participating clubs; the semi-finals and final were each played over one leg at a mini-tournament in a single location (in this instance, in Las Rozas de Madrid).
[10] Quarter-finals Semi-finals Final