After suffering a heavy knock to the head at training on January 18, 2016, defender Justin Clarke was ruled out of football indefinitely, eventually retiring due to long-term health concerns.
[5] Out of contract Collingwood player Jack Frost requested a trade to Brisbane after not managing to play an AFL match in 2016.
[18] Former AFL Queensland employee Breeanna Brock was appointed to the position of Women’s CEO the following day.
[18] Tayla Harris and Sabrina Frederick-Traub were the club's first signings, unveiled along with the league's other 14 marquee players on 27 July 2016.
Brisbane also fielded their reserves team in the North East Australian Football League for the 7th season.