A further 16 teams eliminated from the 2017 CAF Champions League enter the play-off round.

Notably one team takes part in the competition that does not currently play in their national top-division.

[8][9] In the qualifying rounds, each tie was played on a home-and-away two-legged basis.

Notes: The draw for the play-off round was held on 21 March 2017, 11:00 EET (UTC+2), at the CAF Headquarters in Cairo, Egypt.

The draw for the group stage was held on 26 April 2017, 14:00 EET (UTC+2), at the CAF Headquarters in Cairo, Egypt.

[15][16][17] The 16 teams, all winners of the play-off round of qualifying, were drawn into four groups of four.

If tied on points, tiebreakers were applied in the following order (Regulations III.