The Tigers were led by head coach Dabo Swinney in his ninth full year and tenth overall since taking over midway through 2008 season.

The Tigers fell to eventual national champion Alabama in the semifinal game played at the Sugar Bowl, 24–6.

The Tigers hosted out of conference games against Kent State, Auburn, and The Citadel, and traveled to arch rival South Carolina to close out the regular season.

The Tigers played 10 total teams who played in the postseason in the 2016 season: 2 New Year's Six participants (Auburn and Florida State), 7 other bowl teams (Boston College, Georgia Tech, Louisville, NC State, South Carolina, Wake Forest, Virginia Tech), and 1 FCS playoff participant (Citadel).

[33] Quarterback Running back Wide receiver Tight end Placekicker Offensive lineman Defensive lineman Punter Linebacker Defensive back Long snappers [34][35] Sources: Clemson lost six players due to transfer, running back Tyshon Dye, Offensive linemen Jake Fruhmorgen, cornerback Adrian Baker, defensive tackle Scott Pagano, Safety Korrin Wiggins and Defensive end LaSamuel Davis all announced they would transfer from the program.

[36] [37] [38] [39] [40] [41] [42] 1st Team Mitch Hyatt, Tackle Justin Falcinelli, Center Tyrone Crowder, Guard Clelin Ferrell, Defensive End Christian Wilkins, Defensive tackle Dexter Lawrence, Defensive tackle 2nd Team Austin Bryant, Defensive End Dorian O'Daniel, Linebacker 3rd Team Travis Etienne, Running Back Hunter Renfrow, Wide Receiver Deon Cain, Wide Receiver Taylor Hearn, Guard Kendall Joseph, Linebacker