[2] The draw for the first stage was held on 31 January 2017, 21:00 PYST (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.
If still tied, extra time would not be played, and the penalty shoot-out would be used to determine the winner (Regulations Article 6.1).
Tied 2–2 on aggregate, Deportivo Cali won on away goals and advanced to the second stage.
Tied 2–2 on aggregate, Oriente Petrolero won on penalties and advanced to the second stage.
Tied 3–3 on aggregate, Sport Recife won on penalties and advanced to the second stage.
Tied 1–1 on aggregate, Defensa y Justicia won on away goals and advanced to the second stage.