[1][2] Sportivo Limpeño, the defending champions, were eliminated in the group stage.

The qualifying competitions of each association usually end late in the year (September to December).

[22][23] The draw was held on 18 September 2017, 12:00 PYT (UTC−4), at the headquarters of the Paraguayan Football Association.

On 9 October 2017, none of the scheduled Group C matches were played as players from several teams showed symptoms for food poisoning.

[30] The Group B match between Colón and Universitario were further postponed from 13 to 15 October because some players had not yet recovered from food poisoning.