The Rebels played their home games at Vaught–Hemingway Stadium in Oxford, Mississippi and competed in the Western Division of the Southeastern Conference (SEC).

On February 22, 2017, the University of Mississippi self-imposed a one-year ban from post-season play on the Ole Miss football team for the 2017 season, due to alleged NCAA violations.

[1] On July 20, 2017, head coach Hugh Freeze resigned in the wake of allegations about repeated calls to a female escort service from his school-issued cell phone.

The Rebels will host SEC foes Arkansas, LSU, Texas A&M, and Vanderbilt, and will travel to Alabama, Auburn, Kentucky, and Mississippi State.

In total, the NCAA brought 21 distinct charges against the football program, individual coaches and athletic department officials, and boosters.