The Commodores played their home games at Hawkins Field as a member of the Eastern Division of the Southeastern Conference.

The Commodores would finish the regular season 33–21–1 overall, 15–13–1 in conference play and be invited to the 2017 NCAA Division I baseball tournament.

The Commodores finished ranked #10 in the nation and earned a #6 seed in the 2016 Southeastern Conference tournament.

The season was marred by the death of freshman pitcher Donny Everett, who drowned the day before Vanderbilt was to take on Xavier University in their first regional game.

Source: 2017 SEC baseball game results Updated for entire regular season.