CSU Fullerton was a member of the Big West Conference, and participated in their 45th consecutive season in that league.

On March 15, Fullerton defeated UCSB to reach the finals of the Big West tournament, where they played top-seeded UC Irvine in an attempt to reach the NCAA tournament for the second successive year; however, the Titans were handily defeated by the Anteaters, 92–64, in a rematch of the previous year's championship.

The Titans finished in 5th place from defeating Harvard and Sacramento State but losing to Georgia.

In the postseason, CSU Fullerton defeated Long Beach State, UC Davis, and UC Irvine to become champions of the 2018 Big West Conference men's basketball tournament in Anaheim, California.

In addition, the Titans participated in the 2018 NCAA Division I men's basketball tournament, where they lost to Purdue in Detroit, Michigan in the first round.