The 2018–19 Orenburg season was the club's first season return in the Russian Premier League, the highest tier of association football in Russia, following their relegation at the end of the 2016–17, and their second in their 42 year history.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.