The 2019–20 Orenburg season was the club's second season back in the Russian Premier League, the highest tier of association football in Russia, following their relegation at the end of the 2016–17, and their second in their 43-year history.

On 8 December, manager Vladimir Fedotov resigned with Konstantin Yemelyanov being appointed as his replacement.

[5] On 26 June, it was announced that Orenburg's fixture against Krasnodar scheduled for 27 June would not take place due to an outbreak of COVID-19 in the Orenburg squad,[6] and was subsequently awarded to Krasnodar as a 3-0 technical victory.

[8] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.