Porto started the season with a 3–1 victory in the Supertaça Cândido de Oliveira against the 2017–18 Taça de Portugal holders, Desportivo das Aves, which secured the club's 21st Supertaça win and first since 2013.

Porto led the 2018–19 Primeira Liga for more than half of the season, but lost it to Benfica on 2 March 2019, after a 1–2 home defeat.

They advanced to the round of 16 as group winners, where they beat Italian side Roma to qualify for the quarter-finals for the first time since 2015.

For the second consecutive season, they were eliminated from the competition after losing to English side Liverpool.

Total expending: €27.2 million Total income: €65 million Last updated: 5 April 2019Source: FC Porto, O Jogo (in Portuguese) Win Draw Loss Last updated: 25 May 2019 Source: Competitions