The 2018–19 Luxembourg Division of Honour is the 58th season of second-tier association football in Luxembourg.
The season began on 19 August 2018 and will end on 25 May 2019.
[1] Etzella Ettelbruck and Rumelange were promoted to the Luxembourg National Division at the end of the previous season.
[2] They were replaced by Rodange 91 and Esch, who finished in the bottom two positions of the 2017–18 Luxembourg National Division.
[3] Norden 02, Grevenmacher, and Union 05 Kayl-Tétange were relegated at the end of the previous season and were replaced by Atert Bissen, Jeunesse Junglinster, and Koeppchen Wormeldange, who earned promotion from the Luxembourg 1.