[16] In the January transfer window, the club sold out-of-favour striker Manolo Gabbiadini to Italian side Sampdoria for an undisclosed fee.

[19][20] Southampton begun their 2018–19 pre-season preparations with a short tour of China, including matches against German club Schalke 04 and local side Jiangsu Suning.

[25] Shortly after the break, Charlie Austin and Stuart Armstrong struck in a five-minute period to bring the game level, before Elyounoussi's finish gave the Saints the win.

[28] New signing Danny Ings scored his first goal for the club after the break, but the hosts held on for the three points, with Walcott almost doubling his tally late on.

[30] Two weeks later, a second consecutive win of the season at home to Brighton & Hove Albion was denied by a penalty in injury time at the end of the game.

[31] Højbjerg opened the scoring before half-time with a strike from long range, with Ings adding a second after the break from a penalty awarded for a foul on the striker.

[31] Shane Duffy brought the Seagulls back into the game, with Glenn Murray converting an injury time penalty to secure a point for the visitors.

[32] Next was a 2–0 loss at recently promoted Wolverhampton Wanderers, with goals scored by Ivan Cavaleiro (his first touch in the Premier League) and Jonny Castro Otto within the last 11 minutes of the game.

[37] Ings pulled one back with a first-half penalty, but two goals from Raheem Sterling and one from Leroy Sané ensured a convincing win for the league leaders.

[41] Former Leipzig boss Ralph Hasenhüttl was named as Southampton's new manager before the Tottenham game, with his first match in charge to be the fixture against Cardiff City on 8 December.

[6] Hasenhüttl's first game at the club ended in a loss, with Callum Paterson scoring the only goal of the match late on to send the Saints down to 19th in the league table, three points away from safety.

[43] Before half-time, Ings scored a second to put the hosts back in front, although less than ten minutes after the break Mkhitaryan responded in kind to level it for the visitors again.

[43] Shane Long saw a late goal disallowed, but later set up Charlie Austin to score the winner in the 85th minute; Southampton's first win since September saw them move out of the relegation zone for the first time in three weeks.

[46] On the stroke of half-time, however, a shot from Raheem Sterling was deflected into his own goal by James Ward-Prowse, and in injury time a back-post header from Sergio Agüero made it 3–1.

[46] Southampton were unable to mount a comeback in the second half, and Højbjerg was shown a straight red card five minutes from full-time for a tackle on Fernandinho.

[48] Long doubled Southampton's lead in injury time before the break, before Wilfred Ndidi scored a consolation goal for the hosts in the second half.

[49] Southampton entered the 2018–19 EFL Cup in the second round, beating fellow Premier League side Brighton & Hove Albion by a single late goal on 28 August.

[50] Substitute Charlie Austin had a shot blocked on the line by Bernardo late on, but scored in the 88th minute to secure the first win of the season for the visitors.

[51] Another win looked to be likely for the South Coast club, after a lead secured by Danny Ings before the break remained for most of the second half, however a late response from Theo Walcott sent the game to penalties.