The 2018–19 season was UANL's second competitive season and second season in the Liga MX Femenil, the top flight of Mexican women's football.

UANL qualified to the playoffs on both Apertura 2018 and Clausura 2019 tournaments, reaching the final twice.

On the Apertura, Tigres lost the final in penalties against América.

[1] On the Clausura, UANL won the championship defeating Monterrey in a rematch of the Clausura 2018 final.

[2] Source: Competitions