The 2018–19 EHF Challenge Cup was the 22nd edition of the European Handball Federation's third-tier competition for men's handball clubs, running from 6 October 2018 to 19 May 2019.

All draws were held at the European Handball Federation headquarters in Vienna, Austria.

[1] Teams listed first played the first leg at home.

[2] Teams listed first played the first leg at home.

The first legs were played on 17–18 November and the second legs were played on 24–25 November 2018[3] The draw seeding pots for the Last 16 Knockout round were composed as follows:[4]

The draw event was held at the EHF Office in Vienna on Tuesday 19 February 2019.

The final home rights draw was held on 30 April 2019 in Vienna.