The Red Sox went on to defeat the Astros in the ALCS, then win the 2018 World Series over the National League champion Los Angeles Dodgers.

The Red Sox entered the ALDS as the 1 seed, having won the AL East with the best regular season with a record of 108–54, giving them home-field advantage throughout the entire playoffs.

[15] The ceremonial first pitch was thrown by Steve Horgan of the Boston Police Department, who gained notoriety as the "bullpen cop" during Game 2 of the 2013 ALCS.

The Red Sox were unable to score again, with Yankees' relievers Zach Britton and Aroldis Chapman getting the final six outs.

Boston got on the board in the top of the second inning, with Rafael Devers scoring from third on a two-out infield single by Christian Vázquez.

Boston broke the game open in the fourth, sending 11 men to the plate and getting seven runs on six hits, as Yankees starter Luis Severino was pulled for Lance Lynn who in turn was relieved by Chad Green.

Yankees catcher Austin Romine pitched the top of the ninth inning, allowing a two-run homer to Holt, who completed the first postseason cycle in Major League history.

Boston's Game 1 starting pitcher, Chris Sale, made a relief appearance in the bottom of the eighth, retiring the side in order.

Red Sox closer Craig Kimbrel entered to pitch the bottom of the ninth inning, allowing a leadoff walk to Aaron Judge followed by a single by Didi Gregorius, bringing the tying run to the plate.

Kimbrel struck out Giancarlo Stanton, but walked Luke Voit to load the bases, and hit Neil Walker to force in a run.

Former Astros pitcher Mike Scott, the 1986 NLCS MVP and Cy Young Award winner, threw the ceremonial first pitch.

He and Corey Kluber traded hitless innings through the 3rd, before Alex Bregman led off the bottom of the 4th with a home run while Josh Reddick added an RBI single to bring the score to 2–0.

Martin Maldonado homered and Bregman drove in his second run of the day in the 7th while Reddick added another RBI single in the 8th to bring the score to 7–2.

Houston went ahead, 4–2, with three runs in the seventh from two singles, a fielder's choice, error, walk, and a two-RBI double by Marwin González.

Houston extended their lead to 11–2 in the ninth, on a walk, balk, ground out, and RBI single by Alex Bregman.

Cleveland got one run in the last of the ninth, with Edwin Encarnación scoring from third on a wild pitch, followed by Melky Cabrera grounding out to first for the 11–3 final and to give the Astros a series sweep.

With their victory in Game 3, the Astros earned a postseason sweep for the first time in franchise history, advancing to the ALCS to meet the winner of the Red Sox and Yankees series.

According to Jeff Passan of Yahoo Sports, the Cleveland Indians warned the Boston Red Sox that a man representing the Houston Astros might try to steal signs from their dugout in the ALCS.