On September 26, the Cubs clinched a trip to the postseason for the fourth year in a row, marking the longest streak in franchise history.

The Cubs finished the 162-game schedule 95–67, earning a tie with the Milwaukee Brewers for the division and the best record in the National League.

The 2018 season was the second of the last for team broadcasts on long time FTA broadcaster WGN-TV, the 2018-19 offseason was when it was announced that effective Opening Day 2020, the Cubs will be moving to a brand new regional cable TV channel, making them the 4th team overall to have their own cable station, officially ending a 7-decade long presence there.

Construction was started under the seats behind home plate on the first of four premier luxury clubs to be located around the park.

The Cubs eventually loaded the bases via a walk and Tommy La Stella reaching on a catcher's interference.

Kyle Hendricks entered the game in the 12th and, in the 13th with two outs, gave up three straight singles to give the Rockies the 2–1 lead.

(Final regular season stats) Players in bold are on the active roster as of the 2022 season Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; K = Strikeouts; AVG = Batting average; OBP = On base percentage; SLG = Slugging percentage; (Through October 1, 2018) Players in bold are on the active roster as of the 2022 season.