[1] Originally planned from 4 to 18 November the tournament was pushed back two weeks because of the 2019 FIFA Women's World Cup qualification CONCACAF–CONMEBOL play-off which clashed with the timeframe.

Audax were the defending champions, having won the title the previous year as a joint team with Corinthians.

There were eventually three bids for the 2018 Copa Libertadores Femenina: Manaus, Santa Cruz de la Sierra and São Paulo proposed by Iranduba, Deportivo ITA and Corinthians, respectively.

[3] On 11 June 2018, CONMEBOL announced that the tournament would be held in Manaus and Iranduba gained the host association additional berth.

[19] During the tournament, CONMEBOL decided to move the matches scheduled on 25 and 26 November at Estádio Roberto Simonsen to protect the football field of Arena da Amazônia.