The competition ended with Guaraní winning their first title after beating Olimpia 5–3 on penalties in the final following a 2–2 draw.
The winners of each group, as well as the two best second-placed teams qualified for the national stage.
The winners of each group, as well as the two best second-placed teams qualified for the national stage.
This zone included teams from the departments of Presidente Hayes, Boquerón and Alto Paraguay.
This zone included teams from the departments of Cordillera and San Pedro.
The draw for the first round was held on 29 June 2018 and the matches were played from 24 July to 5 September 2018.