The 2018 Holy Cross Crusaders football team represented the College of the Holy Cross as a member of the Patriot League during the 2018 NCAA Division I FCS football season.

Led by first-year head coach Bob Chesney, Holy Cross compiled an overall record of 5–6 with a mark of 4–2 in conference play, tying for second place in the Patriot League.

The Crusaders played their home games at Fitton Field in Worcester, Massachusetts.

The Patriot League released their preseason coaches poll on July 26, 2018, with the Crusaders predicted to finish in fourth place.

[1] The Crusaders placed four players on the preseason all-Patriot League team.