The 2018 Spring Game took place in Bloomington on April 14 at 12 p.m.[1] On January 4, 2018, the Hoosiers announced the hiring of David Ballou as new strength and conditioning coach, following the release of Keith Caton, who served one season in the position.

[36][37] Indiana started the year with three consecutive victories against non-conference opponents FIU, Virginia, and Ball State.

In Big Ten Conference play, the team secured victories against Rutgers and Maryland.

In the last game of the season, with bowl eligibility on the line, Indiana fell to in-state rivals Purdue 21–28 to finish in sixth in the East Division with a final record of 5–7, 2–7 in conference play.

The Hoosiers were led offensively by quarterback Peyton Ramsey, who finished in fourth in the Big Ten Conference with 2,875 passing yards and 19 touchdowns.