Purdue began the year with three consecutive losses, each by less than four points, at the hands of Northwestern, Eastern Michigan, and Missouri.

19 Iowa and finished the regular season in a three-way-tie for second in the West Division with a conference record of 5–4.

Northwestern regained its lead in the second quarter via a 34-yard field goal by Charlie Kuhbander and a one-yard touchdown run by T. J.

Purdue reduced Northwestern's lead to four points following a 27-yard field goal from Evans in the fourth quarter.

Eastern Michigan added 7 points in the first quarter via a 75-yard touchdown pass from Tyler Weigers to Mathew Sexton.

Eastern Michigan regained the lead in the fourth quarter via a nine-yard touchdown run by Breck Turner.

Eastern Michigan finally won the game late in the fourth quarter with a 24-yard field goal by Ryland as time expired.

[26] Purdue and Boston College each scored 7 points in the first quarter via a one-yard touchdown run by D. J. Knox, and Anthony Brown finding Tommy Sweeney on a 15-yard pass.

Purdue scored three times in the second quarter on a one-yard Markell Jones touchdown run, a 37-yard field goal from Spencer Evans and a 42-yard Zico reception from Blough to end the half with a 29–7 lead.

Purdue extended their lead in the third quarter via a seven-yard touchdown reception by Rondale Moore from Blough.

The margin of victory was also Purdue's largest in a Big Ten road game since defeat Indiana in Bloomington, 56–7 in 1997.

David Blough found Isaac Zico with a 13-yard pass reception to give the Boilermakers the only score of the first quarter.

After a fourth down conversion on a fake field goal, Rondale Moore was able to score on a 9-yard reception from Blough to end the half.

In the third quarter Ohio State drove to the red zone for the second time in the game, only to come away with a 23-yard Haubeil field goal, and Purdue scored on a one-yard run from D.J.

[38] Purdue was able to win despite Haskins setting a school record for passing yardage in a single game (470).

The loss was Purdue's eighth in a row to Michigan State, continuing a losing streak that started on Nov. 10, 2007.

[46] Purdue scored the first points in the first quarter by a 36-yard touchdown pass from David Blough to receiver Isaac Zico.

In the second quarter, Miguel Recinos opened off to kick a 34-yard field goal to make the score 14–10, Boilermakers.

On the Boilermakers' opening drive of the second half, David Blough found Terry Wright for a stellar 82-yard reception.

With 2:26 left in the third quarter, David Blough found Terry Wright in the end zone to make the score 35–23.

Boosted by two touchdown runs following an interception from David Blough, the Hawkeyes made the score 35–23 after chasing points again.

However, the Boilermakers were to make a heroic final, last-breath drive and capped their stellar effort with an amazing field goal from Spencer Evans.

Minnesota added 7 more points in the fourth quarter via a 12-yard touchdown pass by Tanner Morgan to Tyler Johnson.

Purdue finally got another score late in the fourth quarter via a nine-yard touchdown pass to Rondale Moore from David Blough.

Wisconsin opened the second half scoring when Jonathan Taylor via an 80-yard touchdown run and a 22-yard field goal by Gaglianone.

Purdue scored first in the fourth quarter on a 20-yard Evans field goal, but two late touchdown receptions by Danny Davis III from Jack Coan of five and 18-yards respectively tied the game before regulation ended.

[57] Purdue scored 7 points in the first quarter via an 11-yard touchdown pass from David Blough to Issac Zico.

Indiana responded with 7 points in the second quarter via an eight-yard touchdown run by Stevie Scott.

Indiana reduced Purdue's lead to seven points following a 23-yard touchdown run from Peyton Ramsey in the fourth quarter.

[58] Purdue finished in 3rd place of the Big Ten West Division with a 5–4 record in conference play.