The 2018 Los Cabos Open (also known as the Abierto Mexicano de Tenis Mifel presentado por Cinemex for sponsorship reasons) was an ATP tennis tournament played on outdoor hard courts.

It was the 3rd edition of the Los Cabos Open, and part of the ATP World Tour 250 series of the 2018 ATP World Tour.

It took place in Los Cabos, Mexico from July 30 through August 5, 2018.

The following players received wildcards into the singles main draw: The following players received entry using a protected ranking into the singles main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: