The 2018 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts.

It was the 50th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP World Tour 250 Series of the 2018 ATP World Tour.

It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 19 through August 25, 2018.

It was the last event on the 2018 US Open Series before the 2018 US Open.

* Rankings are as of August 13, 2018 The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following players received entry as lucky losers: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: